|Application ||WB, E|
|Calculated MW||40601 Da|
|Antigen Region||311-335 aa|
|Other Names||Sphingosine 1-phosphate receptor 1, S1P receptor 1, S1P1, Sphingosine 1-phosphate receptor Edg-1, S1P receptor Edg-1, s1pr1, edg1|
|Target/Specificity||This DANREs1pr1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 311-335 amino acids from the C-terminal region of DANREs1pr1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DANREs1pr1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. This inducible epithelial cell G-protein-coupled receptor may be involved in the processes that regulate the differentiation of endothelial cells. Seems to be coupled to the G(i) subclass of heteromeric G proteins.
Im D.-S., et al. Biochem. Biophys. Res. Commun. 279:139-143(2000).
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