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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   ALOX12B Antibody (C-term) Blocking peptide   

ALOX12B Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession O75342
Other Accession NP_001130.1
Clone Names 80311178
Peptide ID 80311178
Additional Information
Gene ID 242
Other Names Arachidonate 12-lipoxygenase, 12R-type, 12R-LOX, 12R-lipoxygenase, 11311-, Epidermis-type lipoxygenase 12, ALOX12B
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ALOX12B
Function Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12R)- hydroperoxyeicosatetraenoic acid/(12R)-HPETE and minor stereoisomers. In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regulation of the expression of airway mucins.
Cellular Location Cytoplasm {ECO:0000255|PROSITE- ProRule:PRU00726}
Tissue Location Expressed in B-cells, hair follicles, foreskin keratinocytes and adult skin. Also expressed in psoriatic tissue
Research Areas
Citations (0)

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This gene encodes an enzyme involved in the converstion ofarachidonic acid to 12R-hydroxyeicosatetraenoic acid. Mutations inthis gene are associated with nonbullous congenital ichthyosiformerythroderma.


Han, S., et al. Hum. Immunol. 71(7):727-730(2010)Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)Vahlquist, A., et al. J. Invest. Dermatol. 130(2):438-443(2010)Agarwal, S., et al. Exp. Dermatol. 18(11):939-946(2009)Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 18(5):1651-1658(2009)

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$ 80.00
Cat# BP10099b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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