|Other Accession||NP_001138.1, NP_001112359.1, NP_001112360.1|
|Other Names||Angiopoietin-2, ANG-2, ANGPT2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is an antagonist ofangiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2,TEK). The encoded protein disrupts the vascular remodeling abilityof ANGPT1 and may induce endothelial cell apoptosis. Threetranscript variants encoding three different isoforms have beenfound for this gene.
Morrissey, C., et al. Prostate 70(16):1799-1808(2010)Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Bento, C.F., et al. Exp. Physiol. 95(9):955-970(2010)Vrbacky, F., et al. Hematology 15(4):210-214(2010)Chen, J., et al. Biochem. Biophys. Res. Commun. 398(2):212-216(2010)
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