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ADAMTS17 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8TE56 |
|---|---|
| Other Accession | NP_620688.2 |
| Clone Names | 80325127 |
| Gene ID | 170691 |
|---|---|
| Other Names | A disintegrin and metalloproteinase with thrombospondin motifs 17, ADAM-TS 17, ADAM-TS17, ADAMTS-17, 3424-, ADAMTS17 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ADAMTS17 |
|---|---|
| Cellular Location | Secreted, extracellular space, extracellular matrix |
| Tissue Location | Isoform 1 and isoform 2 are expressed at high levels in the lung, brain, whole eye and retina. Isoform 1 shows a weaker expression in the heart, kidney and skeletal muscle. Isoform 2 shows a weaker expression in the kidney, bone marrow and skeletal muscle. Isoform 1 and isoform 2 are expressed at high levels in the fetal heart, kidney, and whole eye, whereas a weak expression is seen in the fetal liver. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the ADAMTS (a disintegrinand metalloproteinase with thrombospondin motifs) protein family.ADAMTS family members share several distinct protein modules,including a propeptide region, a metalloproteinase domain, adisintegrin-like domain, and a thrombospondin type 1 (TS) motif.Individual members of this family differ in the number ofC-terminal TS motifs, and some have unique C-terminal domains. Theprotein encoded by this gene has a high sequence similarity to theprotein encoded by ADAMTS19, another family member. The function ofthis protein has not been determined.
References
Ichikawa, S., et al. J. Bone Miner. Res. 25(8):1821-1829(2010)Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :Morales, J., et al. Am. J. Hum. Genet. 85(5):558-568(2009)Sovio, U., et al. PLoS Genet. 5 (3), E1000409 (2009) :Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)
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