|Other Names||A disintegrin and metalloproteinase with thrombospondin motifs 17, ADAM-TS 17, ADAM-TS17, ADAMTS-17, 3424-, ADAMTS17|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Isoform 1 and isoform 2 are expressed at high levels in the lung, brain, whole eye and retina. Isoform 1 shows a weaker expression in the heart, kidney and skeletal muscle Isoform 2 shows a weaker expression in the kidney, bone marrow and skeletal muscle. Isoform 1 and isoform 2 are expressed at high levels in the fetal heart, kidney, and whole eye, whereas a weak expression is seen in the fetal liver|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the ADAMTS (a disintegrinand metalloproteinase with thrombospondin motifs) protein family.ADAMTS family members share several distinct protein modules,including a propeptide region, a metalloproteinase domain, adisintegrin-like domain, and a thrombospondin type 1 (TS) motif.Individual members of this family differ in the number ofC-terminal TS motifs, and some have unique C-terminal domains. Theprotein encoded by this gene has a high sequence similarity to theprotein encoded by ADAMTS19, another family member. The function ofthis protein has not been determined.
Ichikawa, S., et al. J. Bone Miner. Res. 25(8):1821-1829(2010)Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :Morales, J., et al. Am. J. Hum. Genet. 85(5):558-568(2009)Sovio, U., et al. PLoS Genet. 5 (3), E1000409 (2009) :Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)
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