|Other Names||Stromal interaction molecule 1, STIM1, GOK|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159, PubMed:19249086, PubMed:22464749, PubMed:24069340, PubMed:24351972, PubMed:24591628, PubMed:26322679, PubMed:25326555, PubMed:28219928). Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit ORAI1 (PubMed:16208375, PubMed:16537481). Involved in enamel formation (PubMed:24621671). Activated following interaction with STIMATE, leading to promote STIM1 conformational switch (PubMed:26322679).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Sarcoplasmic reticulum. Note=Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium and is detected at punctae corresponding to junctions between the endoplasmic reticulum and the cell membrane (PubMed:19249086, PubMed:16005298, PubMed:16208375, PubMed:18854159). Associated with the microtubule network at the growing distal tip of microtubules (PubMed:19632184). Colocalizes with ORAI1 at the cell membrane (PubMed:27185316). Colocalizes preferentially with CASQ1 at endoplasmic reticulum in response to a depletion of intracellular calcium (PubMed:27185316).|
|Tissue Location||Ubiquitously expressed in various human primary cells and tumor cell lines.|
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This gene encodes a type 1 transmembrane protein thatmediates Ca2+ influx after depletion of intracellular Ca2+ storesby gating of store-operated Ca2+ influx channels (SOCs). It is oneof several genes located in the imprinted gene domain of 11p15.5,an important tumor-suppressor gene region. Alterations in thisregion have been associated with the Beckwith-Wiedemann syndrome,Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung,ovarian, and breast cancer. This gene may play a role inmalignancies and disease that involve this region, as well as earlyhematopoiesis, by mediating attachment to stromal cells. This geneis oriented in a head-to-tail configuration with the ribonucleotidereductase 1 gene (RRM1), with the 3' end of this gene situated 1.6kb from the 5' end of the RRM1 gene.
Byun, M., et al. J. Exp. Med. 207(11):2307-2312(2010)Park, C.Y., et al. Science 330(6000):101-105(2010)Walsh, C.M., et al. Biochem. J. 430(3):453-460(2010)Hawkins, B.J., et al. J. Cell Biol. 190(3):391-405(2010)Woodward, O.M., et al. PLoS ONE 5 (8), E12305 (2010) :
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