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AGTR1 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P30556 |
|---|---|
| Other Accession | NP_114438.1, NP_114038.1, NP_004826.2, NP_033611.1, NP_000676.1 |
| Clone Names | 80924047 |
| Gene ID | 185 |
|---|---|
| Other Names | Type-1 angiotensin II receptor, AT1AR, AT1BR, Angiotensin II type-1 receptor, AT1, AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | AGTR1 (HGNC:336) |
|---|---|
| Function | Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney (PubMed:1567413, PubMed:8987975, PubMed:15611106, PubMed:25913193, PubMed:26420482, PubMed:30639100, PubMed:32079768). The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C (PubMed:15611106). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Liver, lung, adrenal and adrenocortical adenomas. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Angiotensin II is a potent vasopressor hormone and aprimary regulator of aldosterone secretion. It is an importanteffector controlling blood pressure and volume in thecardiovascular system. It acts through at least two types ofreceptors. This gene encodes the type 1 receptor which is thoughtto mediate the major cardiovascular effects of angiotensin II. Thisgene may play a role in the generation of reperfusion arrhythmiasfollowing restoration of blood flow to ischemic or infarctedmyocardium. It was previously thought that a related gene, denotedas AGTR1B, existed; however, it is now believed that there is onlyone type 1 receptor gene in humans. At least five transcriptvariants have been described for this gene. Additional variantshave been described but their full-length nature has not beendetermined. The entire coding sequence is contained in the terminalexon and is present in all transcript variants. [provided byRefSeq].
References
Xu, M., et al. Atherosclerosis 213(1):191-199(2010)Niu, W., et al. Hypertens. Res. 33(11):1137-1143(2010)Procopciuc, L.M., et al. Eur. J. Intern. Med. 21(5):414-418(2010)Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Schuur, M., et al. J. Neurol. Neurosurg. Psychiatr. (2010) In press :
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