|Other Accession||NP_114438.1, NP_114038.1, NP_004826.2, NP_033611.1, NP_000676.1|
|Other Names||Type-1 angiotensin II receptor, AT1AR, AT1BR, Angiotensin II type-1 receptor, AT1, AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||AGTR1A, AGTR1B, AT2R1, AT2R1B|
|Function||Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Liver, lung, adrenal and adrenocortical adenomas|
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Angiotensin II is a potent vasopressor hormone and aprimary regulator of aldosterone secretion. It is an importanteffector controlling blood pressure and volume in thecardiovascular system. It acts through at least two types ofreceptors. This gene encodes the type 1 receptor which is thoughtto mediate the major cardiovascular effects of angiotensin II. Thisgene may play a role in the generation of reperfusion arrhythmiasfollowing restoration of blood flow to ischemic or infarctedmyocardium. It was previously thought that a related gene, denotedas AGTR1B, existed; however, it is now believed that there is onlyone type 1 receptor gene in humans. At least five transcriptvariants have been described for this gene. Additional variantshave been described but their full-length nature has not beendetermined. The entire coding sequence is contained in the terminalexon and is present in all transcript variants. [provided byRefSeq].
Xu, M., et al. Atherosclerosis 213(1):191-199(2010)Niu, W., et al. Hypertens. Res. 33(11):1137-1143(2010)Procopciuc, L.M., et al. Eur. J. Intern. Med. 21(5):414-418(2010)Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Schuur, M., et al. J. Neurol. Neurosurg. Psychiatr. (2010) In press :
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