|Other Accession||NP_001007226.1, NP_006539.3|
|Other Names||Insulin-like growth factor 2 mRNA-binding protein 2, IGF2 mRNA-binding protein 2, IMP-2, Hepatocellular carcinoma autoantigen p62, IGF-II mRNA-binding protein 2, VICKZ family member 2, IGF2BP2, IMP2, VICKZ2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta- actin/ACTB and MYC transcripts.|
|Cellular Location||Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Localizes at the connecting piece and the tail of the spermatozoa. In response to cellular stress, such as oxidative stress, recruited to stress granules|
|Tissue Location||Expressed in oocytes, granulosa cells of small and growing follicles, Leydig cells, spermatogonia and semen (at protein level). Expressed in testicular cancer (at protein level) Expressed weakly in heart, placenta, skeletal muscle, bone marrow, colon, kidney, salivary glands, testis and pancreas. Detected in fetal liver, fetal ovary, gonocytes and interstitial cells of the testis.|
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This gene encodes a member of the IGF-II mRNA-bindingprotein (IMP) family. The protein encoded by this gene containsseveral four KH domains and two RRM domains. It functions bybinding to the 5' UTR of the insulin-like growth factor 2 (IGF2)mRNA and regulating IGF2 translation. Alternate transcriptionalsplice variants, encoding different isoforms, have beencharacterized.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Pechlivanis, S., et al. Arterioscler. Thromb. Vasc. Biol. 30(9):1867-1872(2010)Heni, M., et al. Diabetes (2010) In press :Rodriguez, S., et al. Growth Horm. IGF Res. 20(4):310-318(2010)Voight, B.F., et al. Nat. Genet. 42(7):579-589(2010)
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