|Other Accession||NP_056362.1, NP_671517.1|
|Other Names||Acyl-coenzyme A thioesterase 11, Acyl-CoA thioesterase 11, 312-, Acyl-CoA thioester hydrolase 11, Adipose-associated thioesterase, Brown fat-inducible thioesterase, BFIT, ACOT11, BFIT, KIAA0707, THEA|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||BFIT, KIAA0707, THEA|
|Function||Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates.|
|Tissue Location||Isoform 1 is predominantly expressed in skeletal muscle, liver, testis, stomach, spleen, lung and brain Isoform 2 is predominantly expressed in kidney, uterus, hibernoma and white adipose tissue|
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This gene encodes a member of the acyl-CoA thioesterasefamily which catalyse the conversion of activated fatty acids tothe corresponding non-esterified fatty acid and coenzyme A.Expression of a mouse homolog in brown adipose tissue is induced bylow temperatures and repressed by warm temperatures. Higher levelsof expression of the mouse homolog has been found inobesity-resistant mice compared with obesity-prone mice, suggestinga role of acyl-CoA thioesterase 11 in obesity. Alternative splicingresults in transcript variants.
Kirkby, B., et al. Prog. Lipid Res. 49(4):366-377(2010)Hunt, M.C., et al. J. Lipid Res. 46(9):2029-2032(2005)Adams, S.H., et al. Biochem. J. 360 (PT 1), 135-142 (2001) :
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