|Other Names||Centromere protein C, CENP-C, Centromere autoantigen C, Centromere protein C 1, CENP-C 1, Interphase centromere complex protein 7, CENPC, CENPC1, ICEN7|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.|
|Cellular Location||Nucleus. Chromosome, centromere, kinetochore Note=Localizes exclusively in the kinetochore domain of centromeres.|
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Centromere protein C 1 is a centromere autoantigen and acomponent of the inner kinetochore plate. The protein is requiredfor maintaining proper kinetochore size and a timely transition toanaphase. A putative pseudogene exists on chromosome 12. [providedby RefSeq].
Gopalakrishnan, S., et al. Hum. Mol. Genet. 18(17):3178-3193(2009)Yosifova, A., et al. J Affect Disord 117 (1-2), 87-97 (2009) :Baranzini, S.E., et al. Hum. Mol. Genet. 18(4):767-778(2009)Trazzi, S., et al. PLoS ONE 4 (6), E5832 (2009) :Seshadri, S., et al. BMC Med. Genet. 8 SUPPL 1, S15 (2007) :
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