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ABCC10 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q5T3U5 |
|---|---|
| Other Accession | NP_258261.2 |
| Clone Names | 90819012 |
| Gene ID | 89845 |
|---|---|
| Other Names | Multidrug resistance-associated protein 7, ATP-binding cassette sub-family C member 10, ABCC10, MRP7, SIMRP7 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ABCC10 |
|---|---|
| Synonyms | MRP7, SIMRP7 |
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as estradiol-17-beta-o- glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:12527806, PubMed:15256465). May contribute to regulate the transport of organic compounds in testes across the blood-testis- barrier (Probable). Mediates multidrug resistance (MDR) in cancer cells by preventing the intracellular accumulation of certain antitumor drugs, such as, docetaxel and paclitaxel (PubMed:15256465, PubMed:23087055). Does not transport glycocholic acid, taurocholic acid, MTX, folic acid, cAMP, or cGMP (PubMed:12527806). |
| Cellular Location | Cell membrane; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:12566991, ECO:0000269|PubMed:15256465}. Basolateral cell membrane; Multi-pass membrane protein. Basal cell membrane; Multi-pass membrane protein. Note=Localized to the basal membrane of Sertoli cells. |
| Tissue Location | In testis, localized to peritubular myoid cells, Leydig cells, along the basal membrane of Sertoli cells, moderately in the adluminal compartment of the seminiferous tubules, and in vascular endothelial cells. [Isoform 2]: Widely expressed. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of thesuperfamily of ATP-binding cassette (ABC) transporters. ABCproteins transport various molecules across extra- andintra-cellular membranes. ABC genes are divided into seven distinctsubfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). ThisABC full-transporter is a member of the MRP subfamily which isinvolved in multi-drug resistance. Multiple transcript variantsencoding different isoforms have been found for this gene.
References
Kuang, Y.H., et al. Biochem. Pharmacol. 79(2):154-161(2010)Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009)Zhou, Y., et al. Biochem. Pharmacol. 77(6):993-1001(2009)Hopper-Borge, E., et al. Cancer Res. 69(1):178-184(2009)Shen, T., et al. PLoS ONE 4 (10), E7520 (2009) :
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