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BCAT1 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P54687 |
|---|---|
| Other Accession | NP_001171563.1, NP_001171562.1, NP_005495.2, NP_001171564.1, NP_001171565.1 |
| Clone Names | 90723018 |
| Gene ID | 586 |
|---|---|
| Other Names | Branched-chain-amino-acid aminotransferase, cytosolic, BCAT(c), Protein ECA39, BCAT1, BCT1, ECA39 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | BCAT1 |
|---|---|
| Synonyms | BCT1, ECA39 |
| Function | Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. |
| Cellular Location | Cytoplasm. |
| Tissue Location | During embryogenesis, expressed in the brain and kidney. Overexpressed in MYC-induced tumors such as Burkitt's lymphoma |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes the cytosolic form of the enzymebranched-chain amino acid transaminase. This enzyme catalyzes thereversible transamination of branched-chain alpha-keto acids tobranched-chain L-amino acids essential for cell growth. Twodifferent clinical disorders have been attributed to a defect ofbranched-chain amino acid transamination: hypervalinemia andhyperleucine-isoleucinemia. As there is also a gene encoding amitochondrial form of this enzyme, mutations in either gene maycontribute to these disorders. Alternatively spliced transcriptvariants have been described.
References
Eijgelsheim, M., et al. Hum. Mol. Genet. 19(19):3885-3894(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Barber, M.J., et al. PLoS ONE 5 (3), E9763 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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