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FOXL2 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P58012
Other Accession NP_075555.1
Clone Names 90625060
Peptide ID 90625060
Additional Information
Gene ID 668
Other Names Forkhead box protein L2, FOXL2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FOXL2
Function Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans- differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00089, ECO:0000269|PubMed:19744555}
Tissue Location In addition to its expression in the developing eyelid, it is transcribed very early in somatic cells of the developing gonad (before sex determination) and its expression persists in the follicular cells of the adult ovary
Research Areas
Citations (0)

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This gene encodes a forkhead transcription factor. Theprotein contains a fork-head DNA-binding domain and may play a rolein ovarian development and function. Mutations in this gene are acause of blepharophimosis syndrome and premature ovarian failure 3.


Nakashima, M., et al. Nat. Genet. 42(9):768-771(2010)Kraoua, L., et al. Clin. Genet. 77(6):601-603(2010)Murphy, B.D. Nat. Med. 16(5):527-529(2010)Corpuz, P.S., et al. Mol. Endocrinol. 24(5):1037-1051(2010)Kim, T., et al. Histopathology 56(3):408-410(2010)

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$ 80.00
Cat# BP10166a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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