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ELL Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P55199
Other Accession NP_006523.1
Clone Names 91009006
Peptide ID 91009006
Additional Information
Gene ID 8178
Other Names RNA polymerase II elongation factor ELL, Eleven-nineteen lysine-rich leukemia protein, ELL, C19orf17
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ELL
Synonyms C19orf17
Function Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation.
Cellular Location Nucleus. Nucleus speckle. Nucleus, Cajal body. Note=Colocalizes with EAF2 to nuclear speckles. Colocalizes with coilin in subnuclear cajal and histone locus bodies Translocates in the LEC complex to cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes
Tissue Location Expressed in all tissues tested. Highest levels found in placenta, skeletal muscle, testis and peripheral blood leukocytes
Research Areas
Citations (0)

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Liu, L., et al. Prostate 70(7):797-805(2010)Zhou, J., et al. J. Biol. Chem. 284(28):19142-19152(2009)Jiang, F., et al. Cancer Lett. 253(2):265-272(2007)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :

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$ 80.00
Cat# BP10171b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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