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PSRC1 Antibody (C-Term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q6PGN9
Other Accession NP_001027462.1, NP_116025.1, NP_001005290.1
Clone Names 91023134
Peptide ID 91023134
Additional Information
Gene ID 84722
Other Names Proline/serine-rich coiled-coil protein 1, PSRC1, DDA3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PSRC1
Synonyms DDA3
Function Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression.
Cellular Location Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Detected at the mitotic spindle and spindle poles. Diffusely distributed throughout the cell during interphase
Tissue Location Widely expressed in adult and fetal tissues, with highest expression in the adult brain and fetal thymus. Not detected in adult skeletal muscle.
Research Areas
Citations (0)

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Background

This gene encodes a proline-rich protein. Studies of thisgene and the related mouse gene suggest that this gene is regulatedby p53 and may participate in p53-mediated growth suppression. Theencoded protein may function as a microtubule destabilizing proteinthat controls spindle dynamics and mitotic progression byrecruiting and regulating microtubule depolymerases. At least onegenetic variation in this gene has been associated with decreasedserum levels of low-density lipoprotein cholesterol. Alternativelyspliced transcript variants encoding different isoforms have beendescribed.

References

Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Roder, C., et al. Childs Nerv Syst (2010) In press :Keebler, M.E., et al. Circ Cardiovasc Genet 3(4):358-364(2010)Hsieh, W.J., et al. Biochem. Biophys. Res. Commun. 369(2):567-572(2008)

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$ 80.00
Cat# BP10177b
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