|Other Accession||NP_001027462.1, NP_116025.1, NP_001005290.1|
|Other Names||Proline/serine-rich coiled-coil protein 1, PSRC1, DDA3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Detected at the mitotic spindle and spindle poles. Diffusely distributed throughout the cell during interphase|
|Tissue Location||Widely expressed in adult and fetal tissues, with highest expression in the adult brain and fetal thymus. Not detected in adult skeletal muscle.|
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This gene encodes a proline-rich protein. Studies of thisgene and the related mouse gene suggest that this gene is regulatedby p53 and may participate in p53-mediated growth suppression. Theencoded protein may function as a microtubule destabilizing proteinthat controls spindle dynamics and mitotic progression byrecruiting and regulating microtubule depolymerases. At least onegenetic variation in this gene has been associated with decreasedserum levels of low-density lipoprotein cholesterol. Alternativelyspliced transcript variants encoding different isoforms have beendescribed.
Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Roder, C., et al. Childs Nerv Syst (2010) In press :Keebler, M.E., et al. Circ Cardiovasc Genet 3(4):358-364(2010)Hsieh, W.J., et al. Biochem. Biophys. Res. Commun. 369(2):567-572(2008)
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