Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
CST8 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O60676 |
|---|---|
| Other Accession | NP_005483.1 |
| Clone Names | 90921047 |
| Gene ID | 10047 |
|---|---|
| Other Names | Cystatin-8, Cystatin-related epididymal spermatogenic protein, CST8, CRES |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CST8 |
|---|---|
| Synonyms | CRES |
| Function | Performs a specialized role during sperm development and maturation. |
| Cellular Location | Secreted. |
| Tissue Location | Proximal caput region of the epididymis. Lower expression in the testis. Within the testis it is localized to the elongating spermatids, whereas within the epididymis it is exclusively synthesized by the proximal caput epithelium |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
The cystatin superfamily encompasses proteins that containmultiple cystatin-like sequences. Some of the members are activecysteine protease inhibitors, while others have lost or perhapsnever acquired this inhibitory activity. There are three inhibitoryfamilies in the superfamily, including the type 1 cystatins(stefins), type 2 cystatins and the kininogens. The type 2 cystatinproteins are a class of cysteine proteinase inhibitors found in avariety of human fluids and secretions. The cystatin locus onchromosome 20 contains the majority of the type 2 cystatin genesand pseudogenes. This gene is located in the cystatin locus andencodes a protein similar to type 2 cystatins. The protein exhibitshighly tissue-specific expression in the reproductive tract,suggesting implicit roles in reproduction. Alternative splicingidentified in mouse is suggested in human based on EST evidence butthe full-length nature of putative variants has not beendetermined.
References
Frygelius, J., et al. Evol. Dev. 12(3):329-342(2010)Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009)Lamesch, P., et al. Genomics 89(3):307-315(2007)Ramachandran, P., et al. J. Proteome Res. 5(6):1493-1503(2006)Wassler, M., et al. Biol. Reprod. 67(3):795-803(2002)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
