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GABRG2 Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P18507
Other Accession NP_000807.2
Clone Names 91009151
Peptide ID 91009151
Additional Information
Gene ID 2566
Other Names Gamma-aminobutyric acid receptor subunit gamma-2, GABA(A) receptor subunit gamma-2, GABRG2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GABRG2
Function Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel.
Cellular Location Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell projection, dendrite {ECO:0000250|UniProtKB:P22723}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P18508}
Research Areas
Citations (0)

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Background

This gene encodes a gamma-aminobutyric acid (GABA)receptor. GABA is the major inhibitory neurotransmitter in themammlian brain, where it acts at GABA-A receptors, which areligand-gated chloride channels. GABA-A receptors are pentameric,consisting of proteins from several subunit classes: alpha, beta,gamma, delta and rho. Mutations in this gene have been associatedwith epilepsy and febrile seizures. Multiple transcript variantsencoding different isoforms have been identified for this gene.

References

Green, E.K., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (7), 1347-1349 (2010) :Jansen, L.A., et al. Epilepsia 51(8):1456-1467(2010)Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :Shi, X., et al. J. Hum. Genet. 55(6):375-378(2010)Kumari, R., et al. Seizure 19(4):237-241(2010)

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$ 80.00
Cat# BP10189c
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