|Other Names||Polypeptide N-acetylgalactosaminyltransferase 4, Polypeptide GalNAc transferase 4, GalNAc-T4, pp-GaNTase 4, Protein-UDP acetylgalactosaminyltransferase 4, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4, GALNT4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has a highest activity toward Muc7, EA2 and Muc2, with a lowest activity than GALNT2. Glycosylates 'Thr-57' of SELPLG.|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
|Tissue Location||Ubiquitous. Highly expressed in mucous cells.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of theUDP-N-acetyl-alpha-D-galactosamine:polypeptideN-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes.GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgiapparatus by catalyzing the transfer of GalNAc to serine andthreonine residues on target proteins. They are characterized by anN-terminal transmembrane domain, a stem region, a lumenal catalyticdomain containing a GT1 motif and Gal/GalNAc transferase motif, anda C-terminal ricin/lectin-like domain. GalNAc-Ts have different,but overlapping, substrate specificities and patterns ofexpression. In vitro, the encoded protein can complement otherGalNAc-Ts in the complete O-glycosylation of the mucin-1 tandemrepeat and can O-glycosylate the P-selectin glycoprotein ligand-1molecule. The coding region of this gene is contained within asingle exon.
O'Halloran, A.M., et al. J. Thromb. Thrombolysis 27(2):175-184(2009)Argueso, P., et al. Invest. Ophthalmol. Vis. Sci. 44(1):86-92(2003)Hassan, H., et al. J. Biol. Chem. 275(49):38197-38205(2000)Bennett, E.P., et al. J. Biol. Chem. 273(46):30472-30481(1998)Bennett, E.P., et al. Glycobiology 8(6):547-555(1998)
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