|Other Names||NEDD4-like E3 ubiquitin-protein ligase WWP1, 632-, Atrophin-1-interacting protein 5, AIP5, TGIF-interacting ubiquitin ligase 1, Tiul1, WW domain-containing protein 1, WWP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.|
|Cellular Location||Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus|
|Tissue Location||Detected in heart, placenta, pancreas, kidney, liver, skeletal muscle, bone marrow, fetal brain, and at much lower levels in adult brain and lung. Isoform 1 and isoform 5 predominate in all tissues tested, except in testis and bone marrow, where isoform 5 is expressed at much higher levels than isoform 1.|
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WW domain-containing proteins are found in all eukaryotesand play an important role in the regulation of a wide variety ofcellular functions such as protein degradation, transcription, andRNA splicing. This gene encodes a protein which contains 4 tandemWW domains and a HECT (homologous to the E6-associated proteincarboxyl terminus) domain. The encoded protein belongs to a familyof NEDD4-like proteins, which are E3 ubiquitin-ligase molecules andregulate key trafficking decisions, including targeting of proteinsto proteosomes or lysosomes. Alternative splicing of this genegenerates at least 6 transcript variants; however, the full lengthnature of these transcripts has not been defined. [provided byRefSeq].
Edwards, T.L., et al. Biochem. J. 423(1):31-39(2009)Li, Y., et al. Oncogene 28(33):2948-2958(2009)Xin, X., et al. Genome Res. 19(7):1262-1269(2009)Chen, C., et al. Int. J. Cancer 124(12):2829-2836(2009)Eastman, S.W., et al. J. Cell Biol. 184(6):881-894(2009)
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