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BHMT Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q93088 |
|---|---|
| Other Accession | NP_001704.2 |
| Clone Names | 90826083 |
| Gene ID | 635 |
|---|---|
| Other Names | Betaine--homocysteine S-methyltransferase 1, BHMT |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | BHMT {ECO:0000303|PubMed:8798461} |
|---|---|
| Function | Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline. |
| Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:O09171}. Nucleus {ECO:0000250|UniProtKB:O09171} Note=Predominantly localized in the cytoplasm with a small fraction detected in the nucleus. Translocates into the nucleus upon oxidative stress. {ECO:0000250|UniProtKB:O09171} |
| Tissue Location | Found exclusively in liver and kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a cytosolic enzyme that catalyzes theconversion of betaine and homocysteine to dimethylglycine andmethionine, respectively. Defects in this gene could lead tohyperhomocyst(e)inemia, but such a defect has not yet beenobserved.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Giusti, B., et al. Thromb. Haemost. 104(2):231-242(2010)Hobbs, C.A., et al. Obstet Gynecol 116 (2 PT 1), 316-322 (2010) :Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
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