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FBXO2 Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9UK22
Other Accession NP_036300.2
Clone Names 91009081
Peptide ID 91009081
Additional Information
Gene ID 26232
Other Names F-box only protein 2, FBXO2, FBX2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FBXO2
Synonyms FBX2
Function Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity).
Cellular Location Cytoplasm. Microsome membrane; Peripheral membrane protein; Cytoplasmic side
Research Areas
Citations (0)

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This gene encodes a member of the F-box protein familywhich is characterized by an approximately 40 amino acid motif, theF-box. The F-box proteins constitute one of the four subunits ofthe ubiquitin protein ligase complex called SCFs(SKP1-cullin-F-box), which function in phosphorylation-dependentubiquitination. The F-box proteins are divided into 3 classes: Fbwscontaining WD-40 domains, Fbls containing leucine-rich repeats, andFbxs containing either different protein-protein interactionmodules or no recognizable motifs. The protein encoded by this genebelongs to the Fbxs class. This protein is highly similar to therat NFB42 (neural F Box 42 kDa) protein which is enriched in thenervous system and may play a role in maintaining neurons in apostmitotic state.


Eom, C.Y., et al. Proc. Natl. Acad. Sci. U.S.A. 100(17):9803-9807(2003)Ilyin, G.P., et al. Gene 296 (1-2), 11-20 (2002) :Yoshida, Y., et al. Nature 418(6896):438-442(2002)Winston, J.T., et al. Curr. Biol. 9(20):1180-1182(1999)Cenciarelli, C., et al. Curr. Biol. 9(20):1177-1179(1999)

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$ 80.00
Cat# BP10212b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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