|Other Names||Gamma-glutamyltransferase light chain 2, Gamma-glutamyltransferase-like protein 4, GGTLC2, GGTL4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Placenta and sigmoid tissues.|
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Provided below are standard protocols that you may find useful for product applications.
Gamma-glutamyltransferase-1 (GGT1; MIM 612346) is amembrane-bound extracellular enzyme that cleaves gamma-glutamylpeptide bonds in glutathione and other peptides and transfers thegamma-glutamyl moiety to acceptors. Autocatalytic cleavage of theGGT1 precursor polypeptide produces a heavy chain and a light chainthat associate with each other to form the functional enzyme. Lightchain-only GGTs, such as GGTLC2, contain a region corresponding tothe GGT1 light chain, but they lack the membrane-anchoring heavychain region (Heisterkamp et al., 2008 [PubMed 18357469]).[suppliedby OMIM].
Heisterkamp, N., et al. Hum. Genet. 123(4):321-332(2008)Dunham, I., et al. Nature 402(6761):489-495(1999)Kawasaki, K., et al. Genome Res. 7(3):250-261(1997)Leh, H., et al. FEBS Lett. 394(3):258-262(1996)Wetmore, L.A., et al. Proc. Natl. Acad. Sci. U.S.A. 90(16):7461-7465(1993)
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