|Other Accession||NP_001165413.1, NP_001112358.1, NP_002054.1, NP_001112357.1|
|Other Names||Glycine receptor subunit alpha-2, GLRA2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).|
|Cellular Location||Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The glycine receptor consists of two subunits, alpha andbeta, and acts as a pentamer. The protein encoded by this gene isan alpha subunit and can bind strychnine. Several transcriptvariants encoding different isoforms have been found for this gene.
Hong, C.W., et al. J. Immunol. 184(8):4401-4413(2010)Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :Tabakoff, B., et al. BMC Biol. 7, 70 (2009) :Lamesch, P., et al. Genomics 89(3):307-315(2007)Miller, P.S., et al. J. Biol. Chem. 280(45):37877-37884(2005)
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