GLRA2 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P23416 |
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Other Accession | NP_001165413.1, NP_001112358.1, NP_002054.1, NP_001112357.1 |
Clone Names | 91013022 |
Gene ID | 2742 |
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Other Names | Glycine receptor subunit alpha-2, GLRA2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GLRA2 (HGNC:4327) |
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Function | Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:15302677, PubMed:16144831, PubMed:23895467, PubMed:25445488, PubMed:26370147, PubMed:34473954). Channel opening is also triggered by taurine and beta-alanine (PubMed:15302677). Plays a role in synaptic plasticity (By similarity). Contributes to the generation of inhibitory postsynaptic currents, and is involved in the down-regulation of neuronal excitability (PubMed:25445488). Plays a role in cellular responses to ethanol (PubMed:23895467). |
Cellular Location | Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q7TNC8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23415}. Synapse {ECO:0000250|UniProtKB:Q7TNC8} Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23415}. Cell projection {ECO:0000250|UniProtKB:Q7TNC8} |
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Provided below are standard protocols that you may find useful for product applications.
Background
The glycine receptor consists of two subunits, alpha andbeta, and acts as a pentamer. The protein encoded by this gene isan alpha subunit and can bind strychnine. Several transcriptvariants encoding different isoforms have been found for this gene.
References
Hong, C.W., et al. J. Immunol. 184(8):4401-4413(2010)Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :Tabakoff, B., et al. BMC Biol. 7, 70 (2009) :Lamesch, P., et al. Genomics 89(3):307-315(2007)Miller, P.S., et al. J. Biol. Chem. 280(45):37877-37884(2005)
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