|Other Names||General transcription factor 3C polypeptide 6, Transcription factor IIIC 35 kDa subunit, TFIIIC 35 kDa subunit, TFIIIC35, Transcription factor IIIC subunit 6, GTF3C6, C6orf51|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.|
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Provided below are standard protocols that you may find useful for product applications.
RNA polymerases are unable to initiate RNA synthesis inthe absence of additional proteins called general transcriptionfactors (GTFs). GTFs assemble in a complex on the DNA promoter andrecruit the RNA polymerase. GTF3C family proteins (e.g., GTF3C1,MIM 603246) are essential for RNA polymerase III to make a numberof small nuclear and cytoplasmic RNAs, including 5S RNA (MIM180420), tRNA, and adenovirus-associated (VA) RNA of both cellularand viral origin.
Dumay-Odelot, H., et al. J. Biol. Chem. 282(23):17179-17189(2007)
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