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KLDC3 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BQ90 |
|---|---|
| Other Accession | NP_476502.1 |
| Clone Names | 91109277 |
| Gene ID | 116138 |
|---|---|
| Other Names | Kelch domain-containing protein 3, Protein Peas, Testis intracellular mediator protein, KLHDC3, PEAS |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | KLHDC3 {ECO:0000303|PubMed:26138980, ECO:0000312|HGNC:HGNC:20704} |
|---|---|
| Function | Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948, PubMed:29775578). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:29779948, PubMed:29775578). The CRL2(KLHDC3) complex specifically recognizes proteins with a glycine (Gly) at the C-terminus, leading to their ubiquitination and degradation: recognizes the C-terminal -Arg-(Xaa)n-Arg-Gly, -Arg- (Xaa)n-Lys-Gly, and -Arg-(Xaa)n-Gln-Gly degrons (PubMed:29779948, PubMed:29775578). The CRL2(KLHDC3) complex mediates ubiquitination and degradation of truncated SELENOV and SEPHS2 selenoproteins produced by failed UGA/Sec decoding, which end with a glycine (PubMed:26138980). May be involved in meiotic recombination process (PubMed:12606021). |
| Cellular Location | Cytoplasm. |
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Background
The protein encoded by this gene contains six repeatedkelch motifs that are structurally similar to recombinationactivating gene 2 (RAG2), a protein involved in the activation ofthe V(D)J recombination. In mouse, this gene is found to expressspecifically in testis. Its expression in pachytene spermatocytesis localized to cytoplasma and meiotic chromatin, which suggeststhat this gene may be involved in meiotic recombination. [providedby RefSeq].
References
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Mungall, A.J., et al. Nature 425(6960):805-811(2003)Ohinata, Y., et al. DNA Res. 10(2):79-84(2003)
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