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FAM19A4 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96LR4 |
|---|---|
| Other Accession | NP_001005527.1, NP_872328.1 |
| Clone Names | 91230137 |
| Gene ID | 151647 |
|---|---|
| Other Names | Protein FAM19A4, Chemokine-like protein TAFA-4, FAM19A4, TAFA4 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TAFA4 (HGNC:21591) |
|---|---|
| Function | Modulates injury-induced and chemical pain hypersensitivity (By similarity). Ligand of FPR1, can chemoattract macrophages, promote phagocytosis and increase ROS release (PubMed:25109685). |
| Cellular Location | Secreted |
| Tissue Location | Expressed in brain (PubMed:15028294). Expressed in LPS-stimulated monocytes and macrophages, especially in polarized M1 (PubMed:25109685). |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the TAFA family which is composedof five highly homologous genes that encode small secretedproteins. These proteins contain conserved cysteine residues atfixed positions, and are distantly related to MIP-1alpha, a memberof the CC-chemokine family. The TAFA proteins are predominantlyexpressed in specific regions of the brain, and are postulated tofunction as brain-specific chemokines or neurokines, that act asregulators of immune and nervous cells. Transcript variants withdifferent 5' UTRs, but encoding the same protein, have been foundfor this gene.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)Tom Tang, Y., et al. Genomics 83(4):727-734(2004)
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