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SPRED3 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q2MJR0 |
|---|---|
| Other Accession | NP_001035987.1 |
| Clone Names | 91230307 |
| Gene ID | 399473 |
|---|---|
| Other Names | Sprouty-related, EVH1 domain-containing protein 3, Spred-3, SPRED3, EVE-3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SPRED3 |
|---|---|
| Synonyms | EVE-3 |
| Function | Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q6P6N5}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q6P6N5} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
SPRED3 is a member of the Sprouty (see SPRY1; MIM602465)/SPRED family of proteins that regulate growthfactor-induced activation of the MAP kinase cascade (see MAPK1; MIM176948) (Nonami et al., 2004 [PubMed 15465815]).
References
King, J.A., et al. J. Hepatol. 44(4):758-767(2006)Nonami, A., et al. J. Biol. Chem. 279(50):52543-52551(2004)Mizoguchi, M., et al. Neurogenetics 5(1):81-82(2004)Kato, R., et al. Biochem. Biophys. Res. Commun. 302(4):767-772(2003)
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