|Other Names||Sprouty-related, EVH1 domain-containing protein 3, Spred-3, SPRED3, EVE-3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase.|
|Cellular Location||Membrane; Peripheral membrane protein|
|Tissue Location||Expression is restricted to liver.|
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Provided below are standard protocols that you may find useful for product applications.
SPRED3 is a member of the Sprouty (see SPRY1; MIM602465)/SPRED family of proteins that regulate growthfactor-induced activation of the MAP kinase cascade (see MAPK1; MIM176948) (Nonami et al., 2004 [PubMed 15465815]).
King, J.A., et al. J. Hepatol. 44(4):758-767(2006)Nonami, A., et al. J. Biol. Chem. 279(50):52543-52551(2004)Mizoguchi, M., et al. Neurogenetics 5(1):81-82(2004)Kato, R., et al. Biochem. Biophys. Res. Commun. 302(4):767-772(2003)
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