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OBFC2A Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96AH0 |
|---|---|
| Other Accession | NP_001026886.1 |
| Clone Names | 100107232 |
| Gene ID | 64859 |
|---|---|
| Other Names | SOSS complex subunit B2, Nucleic acid-binding protein 1, Oligonucleotide/oligosaccharide-binding fold-containing protein 2A, Sensor of single-strand DNA complex subunit B2, Sensor of ssDNA subunit B2, SOSS-B2, Single-stranded DNA-binding protein 2, hSSB2, NABP1, OBFC2A, SSB2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NABP1 |
|---|---|
| Synonyms | OBFC2A, SSB2 |
| Function | Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM- dependent signaling pathways. |
| Cellular Location | Nucleus. Note=Localizes to nuclear foci following DNA damage |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Single-stranded DNA (ssDNA)-binding proteins, such asOBFC2A, are ubiquitous and essential for a variety of DNA metabolicprocesses, including replication, recombination, and detection andrepair of damage (Richard et al., 2008 [PubMed 18449195]).[suppliedby OMIM].
References
Li, Y., et al. J. Biol. Chem. 284(35):23525-23531(2009)Huang, J., et al. Mol. Cell 35(3):384-393(2009)Richard, D.J., et al. Nature 453(7195):677-681(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)
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