|Other Accession||NP_001035995.1, NP_001035997.2, NP_079509.5, NP_001035994.1, NP_001035996.1|
|Other Names||Bifunctional coenzyme A synthase, CoA synthase, NBP, POV-2, Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT, Dephospho-CoA kinase, DPCK, Dephosphocoenzyme A kinase, DPCOAK, COASY|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation.|
|Cellular Location||Cytoplasm. Mitochondrion matrix. Note=The protein is mainly present in the mitochondrial matrix, probably anchored to the inner mitochondrial membrane, but is also present in cell lysate|
|Tissue Location||Expressed in all tissues examined including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocyte. Lowest expression in peripheral blood leukocytes and highest in kidney and liver. Isoform 2 is expressed mainly in the brain.|
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Provided below are standard protocols that you may find useful for product applications.
Biosynthesis of coenzyme A (CoA) from pantothenic acid(vitamin B5) is an essential universal pathway in prokaryotes andeukaryotes. COASY is a bifunctional enzyme that catalyzes the 2last steps in CoA synthesis. These activities are performed by 2separate enzymes, phosphopantetheine adenylyltransferase (PPAT; EC188.8.131.52) and dephospho-CoA kinase (DPCK; EC 184.108.40.206), inprokaryotes (Daugherty et al., 2002 [PubMed 11923312]).[supplied byOMIM].
Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)Breus, O., et al. Biochem. Biophys. Res. Commun. 385(4):581-585(2009)Hamaguchi, M., et al. Jpn. J. Clin. Oncol. 38(11):734-742(2008)Nemazanyy, I., et al. Biochem. Biophys. Res. Commun. 341(4):995-1000(2006)Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
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