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C1orf51 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8N365 |
|---|---|
| Other Accession | NP_653298.1 |
| Clone Names | 91230036 |
| Gene ID | 148523 |
|---|---|
| Other Names | Circadian-associated transcriptional repressor, ChIP-derived repressor of network oscillator, Chrono, Computationally highlighted repressor of the network oscillator, CIART, C1orf51 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CIART |
|---|---|
| Synonyms | C1orf51 |
| Function | Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Abrogates the interaction of BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity). |
| Cellular Location | Nucleus. Nucleus, PML body. Note=Co-localizes with the CLOCK-BMAL1 heterodimer in the PML body. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Lamesch, P., et al. Genomics 89(3):307-315(2007)
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$ 277.78
Cat# BP10380a
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