|Other Names||Integrin alpha-11, ITGA11|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Integrin alpha-11/beta-1 is a receptor for collagen.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||According to PubMed:10464311, highest levels of expression in uterus and heart, intermediate levels in skeletal muscle and intermediate to low levels in pancreas, kidney and placenta. According to PubMed:10486209, also found in brain, colon, lung, small intestine, stomach, testis, salivary glands, thyroid glands and prostate. Very low levels in peripheral blood lymphocytes, fetal brain and fetal liver|
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This gene encodes an alpha integrin. Integrins areheterodimeric integral membrane proteins composed of an alpha chainand a beta chain. This protein contains an I domain, is expressedin muscle tissue, dimerizes with beta 1 integrin in vitro, andappears to bind collagen in this form. Therefore, the protein maybe involved in attaching muscle tissue to the extracellular matrix.Alternative transcriptional splice variants have been found forthis gene, but their biological validity is not determined.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Lu, N., et al. Matrix Biol. 29(3):166-176(2010)Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009)Young, R.P., et al. Postgrad Med J 85(1008):515-524(2009)Barczyk, M.M., et al. J. Dent. Res. 88(7):621-626(2009)
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