|Other Accession||NP_803876.1, NP_958834.1|
|Other Names||Ras association domain-containing protein 6, RASSF6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B (By similarity).|
|Tissue Location||Highest expression in thymus, kidney and placenta. Also detected in colon, small intestine and lung. Tends to be down-regulated in 30-60% of tumors derived from breast, colon, kidney liver, rectum, pancreas, stomach and the thyroid gland compared to the normal counterpart|
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Provided below are standard protocols that you may find useful for product applications.
RASSF6 is a member of the RAS association (RA) domainfamily of RAS effectors/tumor suppressors that mediate some of thegrowth inhibitory properties of RAS (see HRAS; MIM 190020)oncogenes (Eckfeld et al., 2004 [PubMed 15574778]).[supplied byOMIM].
Ikeda, M., et al. Sci Signal 2 (90), RA59 (2009) :Hesson, L.B., et al. Mol. Cancer 8, 42 (2009) :Hillian, A.D., et al. Genes Immun. 9(6):501-508(2008)Allen, N.P., et al. Oncogene 26(42):6203-6211(2007)Ikeda, M., et al. Exp. Cell Res. 313(7):1484-1495(2007)
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