|Other Accession||NP_803876.1, NP_958834.1|
|Other Names||Ras association domain-containing protein 6, RASSF6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B (By similarity).|
|Tissue Location||Highest expression in thymus, kidney and placenta. Also detected in colon, small intestine and lung. Tends to be down-regulated in 30-60% of tumors derived from breast, colon, kidney liver, rectum, pancreas, stomach and the thyroid gland compared to the normal counterpart|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
RASSF6 is a member of the RAS association (RA) domainfamily of RAS effectors/tumor suppressors that mediate some of thegrowth inhibitory properties of RAS (see HRAS; MIM 190020)oncogenes (Eckfeld et al., 2004 [PubMed 15574778]).[supplied byOMIM].
Ikeda, M., et al. Sci Signal 2 (90), RA59 (2009) :Hesson, L.B., et al. Mol. Cancer 8, 42 (2009) :Hillian, A.D., et al. Genes Immun. 9(6):501-508(2008)Allen, N.P., et al. Oncogene 26(42):6203-6211(2007)Ikeda, M., et al. Exp. Cell Res. 313(7):1484-1495(2007)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.