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KBTBD5 Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q2TBA0
Other Accession NP_689606.2
Clone Names 100111213
Additional Information
Gene ID 131377
Other Names Kelch-like protein 40, Kelch repeat and BTB domain-containing protein 5, Sarcosynapsin, KLHL40, KBTBD5, SRYP
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KLHL40 (HGNC:30372)
Function Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development (PubMed:23746549). The BCR(KLHL40) complex acts by mediating ubiquitination and degradation of TFDP1, thereby regulating the activity of the E2F:DP transcription factor complex (By similarity). Promotes stabilization of LMOD3 by acting as a negative regulator of LMOD3 ubiquitination; the molecular process by which it negatively regulates ubiquitination of LMOD3 is however unclear (By similarity).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:Q9D783}. Cytoplasm, myofibril, sarcomere, A band Cytoplasm, myofibril, sarcomere, I band {ECO:0000250|UniProtKB:Q9D783}
Tissue Location Highly expressed in fetal (19, 23 and 31 weeks of gestation) and adult skeletal muscle; expression levels tend to be higher in fetal compared to postnatal muscles (at protein level). Also expressed in fetal and adult heart.
Research Areas
Citations (0)
citation

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References

Gerhard, D.S., et al. Genome Res. 14 (10B), 2121-2127 (2004) :

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$ 277.78
Cat# BP10428c
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