Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
CLDN16 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9Y5I7 |
|---|---|
| Other Accession | NP_006571.1 |
| Clone Names | 90909124 |
| Gene ID | 10686 |
|---|---|
| Other Names | Claudin-16, Paracellin-1, PCLN-1, CLDN16, PCLN1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CLDN16 |
|---|---|
| Synonyms | PCLN1 |
| Function | Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors. |
| Cellular Location | Cell junction, tight junction. Cell membrane; Multi-pass membrane protein |
| Tissue Location | Kidney-specific, including the thick ascending limb of Henle (TAL) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Tight junctions represent one mode of cell-to-celladhesion in epithelial or endothelial cell sheets, formingcontinuous seals around cells and serving as a physical barrier toprevent solutes and water from passing freely through theparacellular space. These junctions are comprised of sets ofcontinuous networking strands in the outwardly facing cytoplasmicleaflet, with complementary grooves in the inwardly facingextracytoplasmic leaflet. The protein encoded by this gene, amember of the claudin family, is an integral membrane protein and acomponent of tight junction strands. It is found primarily in thekidneys, specifically in the thick ascending limb of Henle, whereit acts as either an intercellular pore or ion concentration sensorto regulate the paracellular resorption of magnesium ions. Defectsin this gene are a cause of primary hypomagnesemia, which ischaracterized by massive renal magnesium wasting withhypomagnesemia and hypercalciuria, resulting in nephrocalcinosisand renal failure. This gene and the CLDN1 gene are clustered onchromosome 3q28.
References
Kuo, S.J., et al. Oncol. Rep. 24(3):759-766(2010)Efrati, E., et al. Cell. Physiol. Biochem. 25(6):705-714(2010)Shuen, A.Y., et al. Clin. Chim. Acta 409 (1-2), 28-32 (2009) :Al-Haggar, M., et al. Clin. Exp. Nephrol. 13(4):288-294(2009)Lal-Nag, M., et al. Genome Biol. 10 (8), 235 (2009) :
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Shipping Information
