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DDX11 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q96FC9
Other Accession NP_689651.1, NP_004390.3
Clone Names 80317159
Peptide ID 80317159
Additional Information
Gene ID 1663
Other Names Probable ATP-dependent RNA helicase DDX11, CHL1-related protein 1, hCHLR1, DEAD/H box protein 11, Keratinocyte growth factor-regulated gene 2 protein, KRG-2, DDX11, CHL1, CHLR1, KRG2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DDX11
Synonyms CHL1, CHLR1, KRG2
Function DNA helicase involved in cellular proliferation. Possesses DNA-dependent ATPase and helicase activities. This helicase translocates on single-stranded DNA in the 5' to 3' direction in the presence of ATP and, to a lesser extent, dATP. Its unwinding activity requires a 5'-single-stranded region for helicase loading, since flush-ended duplex structures do not support unwinding. The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended to 500 bp by RPA or the cohesion establishment factor, the Ctf18-RFC (replication factor C) complex activities. Stimulates the flap endonuclease activity of FEN1. Required for normal sister chromatid cohesion. Required for recruitment of bovine papillomavirus type 1 regulatory protein E2 to mitotic chrmosomes and for viral genome maintenance. Required for maintaining the chromosome segregation and is essential for embryonic development and the prevention of aneuploidy. May function during either S, G2, or M phase of the cell cycle. Binds to both single- and double-stranded DNA.
Cellular Location Nucleus. Nucleus, nucleolus. Note=During the early stages of mitosis, localizes to condensed chromatin and is released from the chromatin with progression to metaphase. Also localizes to the spindle poles throughout mitosis and at the midbody at later stages of mitosis (metaphase to telophase). Co- localizes with bovine papillomavirus type 1 regulatory protein E2 at early stages of mitosis
Tissue Location Highly expressed in spleen, B-cells, thymus, testis, ovary, small intestine, and pancreas. Very low expression seen in the brain. Expressed in dividing cells and/or cells undergoing high levels of recombination. No expression is seen in cells signaled to terminally differentiate. Expressed in keratinocyte growth factor-stimulated cells but not in serum, EGF and IL1-beta-treated keratinocytes.
Research Areas
Citations (0)

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DEAD box proteins, characterized by the conserved motifAsp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They areimplicated in a number of cellular processes involving alterationof RNA secondary structure such as translation initiation, nuclearand mitochondrial splicing, and ribosome and spliceosome assembly.Based on their distribution patterns, some members of this familyare believed to be involved in embryogenesis, spermatogenesis, andcellular growth and division. DDX11 encodes a DEAD box protein,which is an enzyme that possesses both ATPase and DNA helicaseactivities. DDX11 is a homolog of the yeast CHL1 gene, and mayfunction to maintain chromosome transmission fidelity and genomestability.


Leman, A.R., et al. J. Cell. Sci. 123 (PT 5), 660-670 (2010) :Farina, A., et al. J. Biol. Chem. 283(30):20925-20936(2008)Parish, J.L., et al. Mol. Cell 24(6):867-876(2006)Parish, J.L., et al. J. Cell. Sci. 119 (PT 23), 4857-4865 (2006) :Vasa-Nicotera, M., et al. Am. J. Hum. Genet. 76(1):147-151(2005)

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$ 80.00
Cat# BP10453c
(40 western blots)
Availability: In Stock
Bulk Size
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