|Other Names||Anaphase-promoting complex subunit 1, APC1, Cyclosome subunit 1, Mitotic checkpoint regulator, Testis-specific gene 24 protein, ANAPC1, TSG24|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
ANAPC1 is 1 of at least 10 subunits of theanaphase-promoting complex (APC), which functions at themetaphase-to-anaphase transition of the cell cycle and is regulatedby spindle checkpoint proteins. The APC is an E3 ubiquitin ligasethat targets cell cycle regulatory proteins for degradation by theproteasome, thereby allowing progression through the cellcycle.
Ohoka, N., et al. Biochem. Biophys. Res. Commun. 392(3):289-294(2010)Wasch, R., et al. Oncogene 29(1):1-10(2010)Fujita, T., et al. Am. J. Pathol. 173(1):217-228(2008)Lima, E.M., et al. Braz. J. Med. Biol. Res. 41(6):539-543(2008)Jin, L., et al. Cell 133(4):653-665(2008)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.