JARID1D (KDM5D/SMCY) Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9BY66 |
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Clone Names | 6080519 |
Gene ID | 8284 |
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Other Names | Lysine-specific demethylase 5D, 11411-, Histocompatibility Y antigen, H-Y, Histone demethylase JARID1D, Jumonji/ARID domain-containing protein 1D, Protein SmcY, KDM5D, HY, HYA, JARID1D, KIAA0234, SMCY |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP1045b was selected from the C-term region of human SMCY. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | KDM5D |
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Synonyms | HY, HYA, JARID1D, KIAA0234, SMCY |
Function | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks. |
Cellular Location | Nucleus {ECO:0000269|PubMed:27185910, ECO:0000269|PubMed:27477906, ECO:0000305} |
Tissue Location | Expression is highly down-regulated in metastatic prostate tumors. |
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Provided below are standard protocols that you may find useful for product applications.
Background
SMCY is a protein containing zinc finger domains. A short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor cells in a female recipient.
References
Iwase,S., Cell 128 (6), 1077-1088 (2007)Lee,M.G., Cell 128 (5), 877-887 (2007)Piper,K.P., Biol. Reprod. 76 (1), 96-101 (2007)
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