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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   JARID1D (KDM5D/SMCY) Antibody (C-term) Blocking peptide   

JARID1D (KDM5D/SMCY) Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9BY66
Clone Names 6080519
Additional Information
Gene ID 8284
Other Names Lysine-specific demethylase 5D, 11411-, Histocompatibility Y antigen, H-Y, Histone demethylase JARID1D, Jumonji/ARID domain-containing protein 1D, Protein SmcY, KDM5D, HY, HYA, JARID1D, KIAA0234, SMCY
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1045b was selected from the C-term region of human SMCY. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KDM5D
Synonyms HY, HYA, JARID1D, KIAA0234, SMCY
Function Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks.
Cellular Location Nucleus {ECO:0000269|PubMed:27185910, ECO:0000269|PubMed:27477906, ECO:0000305}
Tissue Location Expression is highly down-regulated in metastatic prostate tumors.
Research Areas
Citations (0)

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SMCY is a protein containing zinc finger domains. A short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor cells in a female recipient.


Iwase,S., Cell 128 (6), 1077-1088 (2007)Lee,M.G., Cell 128 (5), 877-887 (2007)Piper,K.P., Biol. Reprod. 76 (1), 96-101 (2007)

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$ 80.00
Cat# BP1045b
Availability: In Stock
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