|Other Names||Lysine-specific demethylase 5D, 11411-, Histocompatibility Y antigen, H-Y, Histone demethylase JARID1D, Jumonji/ARID domain-containing protein 1D, Protein SmcY, KDM5D, HY, HYA, JARID1D, KIAA0234, SMCY|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1045b was selected from the C-term region of human SMCY. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||HY, HYA, JARID1D, KIAA0234, SMCY|
|Function||Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis.|
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Provided below are standard protocols that you may find useful for product applications.
SMCY is a protein containing zinc finger domains. A short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor cells in a female recipient.
Iwase,S., Cell 128 (6), 1077-1088 (2007)Lee,M.G., Cell 128 (5), 877-887 (2007)Piper,K.P., Biol. Reprod. 76 (1), 96-101 (2007)
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