|Other Names||P-selectin glycoprotein ligand 1, PSGL-1, Selectin P ligand, CD162, SELPLG|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed on neutrophils, monocytes and most lymphocytes|
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SELPLG is the high affinity counter-receptor forP-selectin on myeloid cells and stimulated T lymphocytes. As such,it plays a critical role in the tethering of these cells toactivated platelets or endothelia expressing P-selectin. Theorganization of the SELPG gene closely resembles that of CD43 andthe human platelet glycoprotein GpIb-alpha both of which have anintron in the 5-prime-noncoding region, a long second exoncontaining the complete coding region, and TATA-less promoters.
Elmas, E., et al. J. Cardiovasc. Electrophysiol. 21(11):1260-1265(2010)Luan, S.L., et al. J. Pathol. 222(2):166-179(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Russo, H.M., et al. Circ. Res. 107(3):388-397(2010)Dick, D.M., et al. Mol. Psychiatry (2010) In press :
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