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ACTL7A Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9Y615 |
|---|---|
| Other Accession | NP_006678.1 |
| Clone Names | 90819044 |
| Gene ID | 10881 |
|---|---|
| Other Names | Actin-like protein 7A, Actin-like-7-alpha, ACTL7A |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ACTL7A |
|---|---|
| Function | May play an important role in formation and fusion of Golgi- derived vesicles during acrosome biogenesis. |
| Cellular Location | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9QY84}. Golgi apparatus {ECO:0000250|UniProtKB:Q9QY84}. Cytoplasm {ECO:0000250|UniProtKB:Q9QY84}. Nucleus {ECO:0000250|UniProtKB:Q9QY84} Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Detected at the Golgi apparatus during acrosome biogenesis. Detected at the subacrosomal layer in round spermatids. Detected in sperm head and tail {ECO:0000250|UniProtKB:Q9QY84} |
| Tissue Location | Strongly expressed in testis. Also expressed in other tissues. |
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Provided below are standard protocols that you may find useful for product applications.
Background
ACTL7A is a member of a familyof actin-related proteins (ARPs) which share significant amino acidsequence identity to conventional actins. Both actins and ARPs havean actin fold, which is an ATP-binding cleft, as a common feature.The ARPs are involved in diverse cellular processes, includingvesicular transport, spindle orientation, nuclear migration andchromatin remodeling. ACTL7A (ACTL7A), and related gene, ACTL7B,are intronless, and are located approximately 4 kb apart in ahead-to-head orientation within the familial dysautonomia candidateregion on 9q31. Based on mutational analysis of the ACTL7A gene inpatients with this disorder, it was concluded that it is unlikelyto be involved in the pathogenesis of dysautonomia. The ACTL7A geneis expressed in a wide variety of adult tissues, however, its exactfunction is not known.
References
Aberg, K., et al. Hum. Biol. 80(2):99-123(2008)Humphray, S.J., et al. Nature 429(6990):369-374(2004)Garvalov, B.K., et al. J. Cell Biol. 161(1):33-39(2003)Coutts, A.S., et al. J. Cell. Sci. 116 (PT 5), 897-906 (2003) :Chadwick, B.P., et al. Genomics 58(3):302-309(1999)
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