|Other Names||Trypsin-3, Brain trypsinogen, Mesotrypsinogen, Serine protease 3, Serine protease 4, Trypsin III, Trypsin IV, PRSS3, PRSS4, TRY3, TRY4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||PRSS4, TRY3, TRY4|
|Function||Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5.|
|Tissue Location||Expressed in pancreas and brain. Also expressed in Paneth cells, at the base of small intestinal crypts|
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Provided below are standard protocols that you may find useful for product applications.
PRSS3 encodes a trypsinogen, which is a member of thetrypsin family of serine proteases. This enzyme is expressed in thebrain and pancreas and is resistant to common trypsin inhibitors.It is active on peptide linkages involving the carboxyl group oflysine or arginine. PRSS3 is localized to the locus of T cellreceptor beta variable orphans on chromosome 9. Four transcriptvariants encoding different isoforms have been described for thisgene.
Jiang, G., et al. Gut 59(11):1535-1544(2010)Nakanishi, J., et al. J. Invest. Dermatol. 130(4):944-952(2010)Salameh, M.A., et al. J. Biol. Chem. 285(3):1939-1949(2010)Rosendahl, J., et al. Pancreatology 10 (2-3), 243-249 (2010) :Koistinen, H., et al. Neuroscience 160(1):97-102(2009)
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