|Other Accession||NP_001035715.1, NP_001035720.1, NP_001035716.1, NP_001035717.1, NP_114430.2, NP_001035718.1, NP_0010|
|Other Names||Neurocalcin-delta, NCALD|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions.|
|Tissue Location||Retina, cerebrum, cerebellum, brain stem, spinal cord, testis, ovary and small intestine|
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NCALD encodes a member of the neuronal calcium sensor(NCS) family of calcium-binding proteins. The protein contains anN-terminal myristoylation signal and four EF-hand calcium bindingloops. The protein is cytosolic at resting calcium levels; however,elevated intracellular calcium levels induce a conformationalchange that exposes the myristoyl group, resulting in proteinassociation with membranes and partial co-localization with theperinuclear trans-golgi network. The protein is thought to be aregulator of G protein-coupled receptor signal transduction.Several alternatively spliced variants of this gene have beendetermined, all of which encode the same protein; additionalvariants may exist but their biological validity has not beendetermined.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Cirulli, E.T., et al. Eur. J. Hum. Genet. 18(7):815-820(2010)Gill, M.B., et al. J. Biol. Chem. 284(21):14503-14512(2009)Venkataraman, V., et al. Biochemistry 47(25):6590-6601(2008)Kamiyama, M., et al. Hum. Genet. 122 (3-4), 397-407 (2007) :
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