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TPSD1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9BZJ3
Other Accession NP_036349.1
Clone Names 91109010
Peptide ID 91109010
Additional Information
Gene ID 23430
Other Names Tryptase delta, Delta-tryptase, HmMCP-3-like tryptase III, Mast cell mMCP-7-like, Tryptase-3, TPSD1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TPSD1
Function Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.
Cellular Location Secreted. Note=Released from the secretory granules upon mast cell activation.
Tissue Location Expressed in colon, lung, heart and synovial tissue. May be specific to mast cells
Research Areas
Citations (0)

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Tryptases comprise a family of trypsin-like serineproteases, the peptidase family S1. Tryptases are enzymaticallyactive only as heparin-stabilized tetramers, and they are resistantto all known endogenous proteinase inhibitors. Several tryptasegenes are clustered on chromosome 16p13.3. These genes arecharacterized by several distinct features. They have a highlyconserved 3' UTR and contain tandem repeat sequences at the 5'flank and 3' UTR which are thought to play a role in regulation ofthe mRNA stability. Although this gene may be an exception, most ofthe tryptase genes have an intron immediately upstream of theinitiator Met codon, which separates the site of transcriptioninitiation from protein coding sequence. This feature ischaracteristic of tryptases but is unusual in other genes.Tryptases have been implicated as mediators in the pathogenesis ofasthma and other allergic and inflammatory disorders. TPSD1 wasonce considered to be a pseudogene, although it is now believed tobe a functional gene that encodes a protein.


Jackson, N.E., et al. J. Biol. Chem. 283(49):34178-34187(2008)Caughey, G.H. J. Allergy Clin. Immunol. 117(6):1411-1414(2006)Wang, H.W., et al. J. Immunol. 169(9):5145-5152(2002)Caughey, G.H. Mol. Immunol. 38 (16-18), 1353-1357 (2002) :Soto, D., et al. Clin. Exp. Allergy 32(7):1000-1006(2002)

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$ 80.00
Cat# BP10500b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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