|Other Accession||NP_001018099.1, NP_078887.2|
|Other Names||Little elongation complex subunit 2, Interactor of little elongator complex ELL subunit 2, NMDA receptor-regulated protein 2, ICE2, BRCC1, NARG2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III.|
|Cellular Location||Nucleus. Note=Colocalizes with COIL in subnuclear Cajal and histone locus bodies. Translocates in the LEC complex to Cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes|
|Tissue Location||Expressed at low levels in lung and testis.|
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NARG2 is expressed at relatively high levels in dividing and immature cells, and is down-regulated upon terminal differentiation. NARG2 is a novel (S/T)PXX motif-containing nuclear protein; this motif is present in many transcription factors as well as other regulatory proteins that bind to DNA such as histones and RNA polymerase II. Three different isoforms exist.
Sugiura, N., et al. Eur. J. Biochem. 271 (23-24), 4629-4637 (2004) :Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)Sugiura, N., et al. J. Biol. Chem. 276(17):14257-14263(2001)
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