|Other Names||NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11, Complex I-B147, CI-B147, NADH-ubiquinone oxidoreductase subunit B147, NDUFA11|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).|
|Cellular Location||Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side|
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NDUFA11 encodes a subunit of the membrane-boundmitochondrial complex I. Complex I is composed of numerous subunitsand functions as the NADH-ubiquinol reductase of the mitochondrialelectron transport chain. Mutations in this gene are associatedwith severe mitochondrial complex I deficiency. Alternate splicingresults in multiple transcript variants.
Berger, I., et al. Ann. Neurol. 63(3):405-408(2008)Takagaki, K., et al. Biochem. Biophys. Res. Commun. 309(2):351-358(2003)Murray, J., et al. J. Biol. Chem. 278(16):13619-13622(2003)Carroll, J., et al. J. Biol. Chem. 277(52):50311-50317(2002)Carroll, J., et al. J. Biol. Chem. 277(52):50311-50317(2002)
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