|Other Names||Class E basic helix-loop-helix protein 40, bHLHe40, Class B basic helix-loop-helix protein 2, bHLHb2, Differentially expressed in chondrocytes protein 1, DEC1, Enhancer-of-split and hairy-related protein 2, SHARP-2, Stimulated by retinoic acid gene 13 protein, BHLHE40, BHLHB2, DEC1, SHARP2, STRA13|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||BHLHB2, DEC1, SHARP2, STRA13|
|Function||Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity. May be involved in the regulation of chondrocyte differentiation via the cAMP pathway.|
|Cellular Location||Cytoplasm. Nucleus. Note=Predominantly localized in the nucleus (PubMed:11278694).|
|Tissue Location||Expressed in cartilage, spleen, intestine, lung, and to a lesser extent in heart, brain, liver, muscle and stomach|
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BHLHE40 encodes a basic helix-loop-helix proteinexpressed in various tissues. Expression in the chondrocytes isresponsive to the addition of Bt2cAMP. The encoded protein isbelieved to be involved in the control of cell differentiation.
Wang, W., et al. Biochem. Biophys. Res. Commun. 401(3):422-428(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Soria, V., et al. Neuropsychopharmacology 35(6):1279-1289(2010)Utge, S.J., et al. PLoS ONE 5 (2), E9259 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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