|Other Names||Cocaine esterase, Carboxylesterase 2, CE-2, hCE-2, Methylumbelliferyl-acetate deacetylase 2, CES2, ICE|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine.|
|Cellular Location||Endoplasmic reticulum lumen.|
|Tissue Location||Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum.|
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Provided below are standard protocols that you may find useful for product applications.
CES2 is a member of the carboxylesterase largefamily. The family members are responsible for the hydrolysis ortransesterification of various xenobiotics, such as cocaine andheroin, and endogenous substrates with ester, thioester, or amidebonds. They may participate in fatty acyl and cholesterol estermetabolism, and may play a role in the blood-brain barrier system.The protein encoded by this gene is the major intestinal enzyme andfunctions in intestine drug clearance.
Holmes, R.S., et al. Mamm. Genome 21 (9-10), 427-441 (2010) :Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Howard, T.D., et al. Environ. Health Perspect. 118(10):1395-1399(2010)Hatfield, M.J., et al. Br. J. Pharmacol. 160(8):1916-1928(2010)Holmes, R.S., et al. Genetica 138(7):695-708(2010)
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