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ANG Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P03950
Clone Names 80722014
Peptide ID 80722014
Additional Information
Gene ID 283
Other Names Angiogenin, 3127-, Ribonuclease 5, RNase 5, ANG, RNASE5
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ANG
Synonyms RNASE5
Function Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.
Cellular Location Nucleus. Secreted, extracellular space, extracellular matrix, basement membrane. Nucleus, nucleolus. Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA
Tissue Location Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons
Research Areas
Citations (0)

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ANG is an exceedingly potentmediator of new blood vessel formation. It hydrolyzes cellulartRNAs resulting in decreased protein synthesis and is similar topancreatic ribonuclease.


Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Millecamps, S., et al. J. Med. Genet. 47(8):554-560(2010)Cho, G.W., et al. Mol. Cell. Biochem. 340 (1-2), 133-141 (2010) :Tsai, C.P., et al. Neurobiol. Aging (2010) In press :Romero, R., et al. Am. J. Obstet. Gynecol. 202 (5), 431 (2010) :

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$ 80.00
Cat# BP10663c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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