|Other Names||Angiogenin, 3127-, Ribonuclease 5, RNase 5, ANG, RNASE5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.|
|Cellular Location||Nucleus. Secreted, extracellular space, extracellular matrix, basement membrane. Nucleus, nucleolus. Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA|
|Tissue Location||Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons|
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Provided below are standard protocols that you may find useful for product applications.
ANG is an exceedingly potentmediator of new blood vessel formation. It hydrolyzes cellulartRNAs resulting in decreased protein synthesis and is similar topancreatic ribonuclease.
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Millecamps, S., et al. J. Med. Genet. 47(8):554-560(2010)Cho, G.W., et al. Mol. Cell. Biochem. 340 (1-2), 133-141 (2010) :Tsai, C.P., et al. Neurobiol. Aging (2010) In press :Romero, R., et al. Am. J. Obstet. Gynecol. 202 (5), 431 (2010) :
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