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ANG Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P03950 |
|---|---|
| Clone Names | 80722014 |
| Gene ID | 283 |
|---|---|
| Other Names | Angiogenin, 3127-, Ribonuclease 5, RNase 5, ANG, RNASE5 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ANG |
|---|---|
| Synonyms | RNASE5 |
| Function | Ribonuclease that cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs) (PubMed:1400510, PubMed:21855800). Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus (PubMed:8127865). Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA (PubMed:12051708). Angiogenin induces vascularization of normal and malignant tissues (PubMed:19354288). Angiogenic activity is regulated by interaction with RNH1 in vivo (PubMed:19354288). |
| Cellular Location | Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000250|UniProtKB:Q3TMQ6}. Secreted {ECO:0000250|UniProtKB:P10152}. Nucleus. Nucleus, nucleolus. Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA (PubMed:12051708) |
| Tissue Location | Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
ANG is an exceedingly potentmediator of new blood vessel formation. It hydrolyzes cellulartRNAs resulting in decreased protein synthesis and is similar topancreatic ribonuclease.
References
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Millecamps, S., et al. J. Med. Genet. 47(8):554-560(2010)Cho, G.W., et al. Mol. Cell. Biochem. 340 (1-2), 133-141 (2010) :Tsai, C.P., et al. Neurobiol. Aging (2010) In press :Romero, R., et al. Am. J. Obstet. Gynecol. 202 (5), 431 (2010) :
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