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CD11b Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P11215
Clone Names 81020009
Peptide ID 81020009
Additional Information
Gene ID 3684
Other Names Integrin alpha-M, CD11 antigen-like family member B, CR-3 alpha chain, Cell surface glycoprotein MAC-1 subunit alpha, Leukocyte adhesion receptor MO1, Neutrophil adherence receptor, CD11b, ITGAM, CD11B, CR3A
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CD11B, CR3A
Function Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Predominantly expressed in monocytes and granulocytes
Research Areas
Citations (0)

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CD11b is the integrin alpha M chain. Integrinsare heterodimeric integral membrane proteins composed of an alphachain and a beta chain. This I-domain containing alpha integrincombines with the beta 2 chain (ITGB2) to form a leukocyte-specificintegrin referred to as macrophage receptor 1 ('Mac-1'), orinactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2integrin is important in the adherence of neutrophils and monocytesto stimulated endothelium, and also in the phagocytosis ofcomplement coated particles.


Gjelstrup, L.C., et al. J. Immunol. 185(7):4154-4168(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Warchol, T., et al. DNA Cell Biol. (2010) In press :Fan, Y., et al. J Eur Acad Dermatol Venereol (2010) In press :Pliyev, B.K., et al. Biochem. Biophys. Res. Commun. 397(2):277-282(2010)

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$ 80.00
Cat# BP10668a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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