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CD11b Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P11215 |
|---|---|
| Clone Names | 81020009 |
| Gene ID | 3684 |
|---|---|
| Other Names | Integrin alpha-M, CD11 antigen-like family member B, CR-3 alpha chain, Cell surface glycoprotein MAC-1 subunit alpha, Leukocyte adhesion receptor MO1, Neutrophil adherence receptor, CD11b, ITGAM, CD11B, CR3A |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ITGAM |
|---|---|
| Synonyms | CD11B, CR3A |
| Function | Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PubMed:9558116, PubMed:20008295). It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Membrane raft; Single-pass type I membrane protein |
| Tissue Location | Predominantly expressed in monocytes and granulocytes (PubMed:1346576). Expressed in neutrophils (at protein level) (PubMed:21193407). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
CD11b is the integrin alpha M chain. Integrinsare heterodimeric integral membrane proteins composed of an alphachain and a beta chain. This I-domain containing alpha integrincombines with the beta 2 chain (ITGB2) to form a leukocyte-specificintegrin referred to as macrophage receptor 1 ('Mac-1'), orinactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2integrin is important in the adherence of neutrophils and monocytesto stimulated endothelium, and also in the phagocytosis ofcomplement coated particles.
References
Gjelstrup, L.C., et al. J. Immunol. 185(7):4154-4168(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Warchol, T., et al. DNA Cell Biol. (2010) In press :Fan, Y., et al. J Eur Acad Dermatol Venereol (2010) In press :Pliyev, B.K., et al. Biochem. Biophys. Res. Commun. 397(2):277-282(2010)
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