|Other Names||Cyclin-T1, CycT1, Cyclin-T, CCNT1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes.|
|Tissue Location||Ubiquitously expressed.|
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Provided below are standard protocols that you may find useful for product applications.
CCNT1 belongs to the highlyconserved cyclin family, whose members are characterized by adramatic periodicity in protein abundance through the cell cycle.Cyclins function as regulators of CDK kinases. Different cyclinsexhibit distinct expression and degradation patterns whichcontribute to the temporal coordination of each mitotic event. Thiscyclin tightly associates with CDK9 kinase, and was found to be amajor subunit of the transcription elongation factor p-TEFb. Thekinase complex containing this cyclin and the elongation factor caninteract with, and act as a cofactor of human immunodeficiencyvirus type 1 (HIV-1) Tat protein, and was shown to be bothnecessary and sufficient for full activation of viraltranscription. This cyclin and its kinase partner were also foundto be involved in the phosphorylation and regulation of thecarboxy-terminal domain (CTD) of the largest RNA polymerase IIsubunit.
Moiola, C., et al. Cell Cycle 9(15):3119-3126(2010)Schonichen, A., et al. Biochemistry 49(14):3083-3091(2010)Czudnochowski, N., et al. J. Mol. Biol. 395(1):28-41(2010)Kapasi, A.J., et al. J. Virol. 83(11):5904-5917(2009)Cho, S., et al. EMBO J. 28(10):1407-1417(2009)
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