|Other Names||Cannabinoid receptor 2, CB-2, CB2, hCB2, CX5, CNR2, CB2A, CB2B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Perikaryon Note=Localizes to apical dendrite of pyramidal neurons|
|Tissue Location||Preferentially expressed in cells of the immune system with higher expression in B-cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root ganglion sensory neurons (at protein level). Two isoforms are produced by alternative promoter usage and differ only in the 5' UTR: isoform CB2A is observed predominantly in testis with some expression in brain, while isoform CB2B is predominant in spleen and leukocytes|
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The cannabinoid delta-9-tetrahydrocannabinol is theprincipal psychoactive ingredient of marijuana. The proteinsencoded by this gene and the cannabinoid receptor 1 (brain) (CNR1)gene have the characteristics of a guanine nucleotide-bindingprotein (G-protein)-coupled receptor for cannabinoids. They inhibitadenylate cyclase activity in a dose-dependent, stereoselective,and pertussis toxin-sensitive manner. These proteins have beenfound to be involved in the cannabinoid-induced CNS effects(including alterations in mood and cognition) experienced by usersof marijuana. The cannabinoid receptors are members of family 1 ofthe G-protein-coupled receptors.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Larrinaga, G., et al. Histol. Histopathol. 25(9):1133-1138(2010)Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :Taylor, A.H., et al. Histochem. Cell Biol. 133(5):557-565(2010)De Jesus, M.L., et al. Neurochem. Int. 56 (6-7), 829-833 (2010) :
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