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HP Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P00738
Clone Names 90713084
Peptide ID 90713084
Additional Information
Gene ID 3240
Other Names Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain, HP
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HP
Function As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.
Cellular Location Secreted.
Tissue Location Expressed by the liver and secreted in plasma.
Research Areas
Citations (0)

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This gene encodes a preproprotein, which is processed toyield both alpha and beta chains, which subsequently combine as atetramer to produce haptoglobin. Haptoglobin functions to bind freeplasma hemoglobin, which allows degradative enzymes to gain accessto the hemoglobin, while at the same time preventing loss of ironthrough the kidneys and protecting the kidneys from damage byhemoglobin. Mutations in this gene and/or its regulatory regionscause ahaptoglobinemia or hypohaptoglobinemia. This gene has alsobeen linked to diabetic nephropathy, the incidence of coronaryartery disease in type 1 diabetes, Crohn's disease, inflammatorydisease behavior, primary sclerosing cholangitis, susceptibility toidiopathic Parkinson's disease, and a reduced incidence ofPlasmodium falciparum malaria. A similar duplicated gene is locatednext to this gene on chromosome 16. Multiple transcript variantsencoding different isoforms have been found for this gene.


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)Savy, M., et al. PLoS ONE 5 (6), E11075 (2010) :Kasvosve, I., et al. Adv Clin Chem 50, 23-46 (2010) :

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$ 80.00
Cat# BP10680c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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